Neoantigens are unique markers that distinguish only cancer cells. By adding B cell reactivity, cancer vaccines can move beyond one-time attacks and short-term memory to become a long-term immunity ...

B cell development in swine presents a unique model within mammalian immunology. In contrast to traditional murine and human systems, swine exhibit notable differences in the temporal order of heavy ...

New findings show that the stage of normal cell development at which B cells transform into leukemic cells impacts treatment outcomes for pediatric patients with B-cell acute lymphoblastic leukemia (B ...

The illustration depicts how during differentiation cells normally lose their plasticity and ability to acquire new fates. However, when fully differentiated B cells (naive B cells) initiate an immune ...

The fear of cancer stems from the dread that it can recur at any time, even after treatment. A South Korean research team has unveiled a new personalized cancer vaccine technology that enables the ...

Immune cells called B cells make antibodies that fight off invading bacteria, viruses and other foreign substances. During their preparation for this battle, B cells transiently revert to a more ...

Sonrotoclax is a next-generation and potentially best-in-class investigational B-cell lymphoma 2 (BCL2) inhibitor with a unique pharmacokinetic and pharmacodynamic profile. Studies in the lab and ...

As scientists uncover how age-altered antibodies ignite inflammation and tissue decline, a new era of immune-based anti-aging therapies is beginning to emerge. Aging affects B cells and induces ...

Our immune systems have the thankless jobs of guarding us from bacterial and viral invaders and preventing cancer development. Most of the time, we do not notice this hard work because the invaders ...