In some cases, HR-positive/HER2-negative breast cancers may over time become resistant to endocrine therapy. This can occur through mutations in the estrogen receptor ...

"Medical Journeys" is a set of clinical resources reviewed by physicians, meant for the medical team as well as the patients they serve. Each episode of this 12-part journey through a disease state ...

Toward the goal of elucidating endocrine system aging mechanisms, this study establishes the first single-cell aging atlas across multiple endocrine organs. The research reveals conserved aging ...

A team of scientists at the Garvan Institute of Medical Research has discovered that inactivation of a stress pathway makes ER+ breast cancer cells ignore stress signals, allowing them to evade ...

Researchers identify a possible therapeutic target to prevent endocrine autoimmune adverse effects during checkpoint inhibitor immunotherapy. A study led by researchers at the University of California ...

Association of BRCA1 Mutations With Occult Primary Ovarian Insufficiency: A Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks Using a custom microarray, we analyzed ...