PD-1 is an immune checkpoint and guards against autoimmunity through two mechanisms. First, it promotes apoptosis (programmed cell death) of antigen -specific T-cells in lymph nodes. …

Programmed Cell Death Protein 1 (PD-1) plays a vital role in inhibiting immune responses and promoting self-tolerance through modulating the activity of T-cells, activating apoptosis of …

May 16, 2023 · Programmed cell death 1 receptor (PD-1) and its ligands constitute an inhibitory pathway to mediate the mechanism of immune tolerance and provide immune homeostasis. …

Jan 1, 2023 · Programmed Cell Death-1 (PCD-1) is a key immune checkpoint receptor, which mainly expresses on activated T, B, Dendritic (DC), Natural Killer (NK), and Treg cells.

Nov 14, 2025 · Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those …

May 12, 2025 · In recent years, extensive research on the mechanisms of action of programmed death-1 ligand 1 (PD-L1) uncovered the multiple facets of this immune checkpoint molecule on …

New treatments have been developed that target these cancer cells by blocking the interaction of PD-1 and PD-L1, restoring T-cell function. The one shown here is pembrolizumab, an antibody …

Apr 16, 2025 · Programmed cell death protein 1 (PD-1) is frequently detected in certain subsets of tumor cells, and our understanding of PD-1 signaling consequences has expanded to include …

Programmed cell death Programmed cell death (PCD) sometimes referred to as cell, or cellular suicide[1][2][3] is the death of a cell as a result of events inside of a cell, such as apoptosis or …

Programmed cell death (PCD) is essential for generation of the complex structural and functional organization of various organs and systems in the living organism. Most of the cells …