Can high-sensitivity C-reactive protein (CRP), low-density lipoprotein (LDL) cholesterol, and lipoprotein(a) levels be used to predict cardiovascular risk over a long period of time? NEJM Editorial Fellow Sarah Gorey breaks down the Women’s Health Study in this 60-Second Journal Club. Full study: https://nej.md/3Mrh9A8 | The New England Journal of Medicine

🧠 Does Your Brain Need High Cholesterol to Function? 🩺 A recent study published in NEJM Evidence investigated the long-term cognitive effects of achieving very low levels of low-density lipoprotein (LDL) cholesterol using evolocumab, a PCSK9 inhibitor. Participants, already on statin therapy, were assessed over a median of 5.1 years. The findings revealed no significant impact on cognitive function over time, suggesting that intensive LDL cholesterol reduction is safe for both heart and brain